Yang, X-D, Mahapatra, D.R., and Melnik, R.V.N.
Computational Models for Life Sciences -CMLS'07: 2007 Intern. Symposium on Computational Models of Life Sciences, AIP (American Institute of Physics) Conf. Proc., Vol 2, 2007, Vol. 952, pp. 229--237, 2007
The synthesis of dsRNA is analyzed using a pathway model with amplifications caused by the aberrant RNAs. Thetransgene influx rate is assumed time-decaying considering the fact that the number of transgenes can not be infinite. The dynamics of the transgene induced RNA silencing is investigated using a system of coupled nonautonomous ordinary nonlinear differential equations which describe the model phenomenologically. The silencing phenomena are detected after a period of transcription. Important contributions of certain parameters are discussed with several numerical examples.
Keywords: RNA silencing pathway; computational models; RNAi; dynamics
Publication is abstracted/indexed in the Web of Knowledge and other major databases.