Modelling and Control of Flow in Airblast Atomisers for Pulmonary Drug Delivery

Melnik, R.V.N. and Jenkins, D. R.

International Journal of Pharmaceutics , 239, 23--35, 2002

Abstract:

Among different approaches to successful pharmacotherapy the pulmonary drug delivery (PDD) mode plays an increasingly important rote. In this paper PDD systems based on air-blast atomisation have been analysed mathematically. In order to allow the bioengineer to estimate the degree of effectiveness of a specific system prototype and to lay the basic principles for design, a conservation-law-based mathematical model is discussed. Key control parameters that allow improvement in the efficiency of the system have been identified and main characteristics of the system have been analysed numerically as functions or these parameters.